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      Effectiveness of Electrolyzed Oxidized Water Irrigation in a Burn-Wound Infection Model

        Hajime Nakae, MD, PhD,
        and Hideo Inaba, MD, PhD

        The Journal of TRAUMA Injury, Infection, and Critical Care 2000;49:511–514.

      Abstract

        Objective: The purpose of the study was to determine whether electrolyzed oxidized water (EOW) functions as a bactericide in burn injury with Pseudomonas aeruginosa infection in a rat burn-wound model.

        Methods: Anesthetized Sprague-Dawley rats (n = 31) were subjected to third-degree burns to 30% of total body surface area. Two days after injury, all rats were infected with P. aeruginosa using 1 mL of a suspension containing 1 x 108 colony-forming units. Rats were assigned to one of three groups: no irrigation (group I), irrigation with physiologic saline (group II), or irrigation with EOW (group III). Blood culture, endotoxin levels, and survival rates were determined.

        Results: Survival rate was significantly higher in group III than in groups I or II (p < 0.0001). Serum endotoxin levels on day 3 after infection in group III were significantly lower than the levels in group I (p < 0.01) and group II (p < 0.01). There were significant differences between the three groups in the culture of P. aeruginosa (p < 0.05).

        Conclusion: Irrigation and disinfection with EOW may become useful in preventing burn-wound sepsis.

        Key Words: Electrolyzed oxidized water, Burn-wound
        infection, Pseudomonas aeruginosa infection.

        To download the .pdf of the entire study, please click here.

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